{"id":241126,"date":"2026-07-18T04:15:14","date_gmt":"2026-07-18T09:15:14","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/activation-mechanism-and-structural-assembly-of-the-mycobacterium-tuberculosis-clpp1p2-protease-and-its-associated-atpases"},"modified":"2026-07-18T04:15:14","modified_gmt":"2026-07-18T09:15:14","slug":"activation-mechanism-and-structural-assembly-of-the-mycobacterium-tuberculosis-clpp1p2-protease-and-its-associated-atpases","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/activation-mechanism-and-structural-assembly-of-the-mycobacterium-tuberculosis-clpp1p2-protease-and-its-associated-atpases","title":{"rendered":"Activation mechanism and structural assembly of the Mycobacterium tuberculosis ClpP1P2 protease and its associated ATPases"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/activation-mechanism-and-structural-assembly-of-the-mycobacterium-tuberculosis-clpp1p2-protease-and-its-associated-atpases2.jpg\"><\/a><\/p>\n<p>Weinh\u00e4upl et al. determine the cryo-EM structure of the ClpC1P1P2 complex from <i><i>Mycobacterium<\/i> tuberculosis<\/i>, revealing an asymmetric architecture and selective activator binding. They show that molecular crowding promotes assembly and activation of Clp complexes, suggesting a mechanism for ClpP1P2 activation under physiological conditions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Weinh\u00e4upl et al. determine the cryo-EM structure of the ClpC1P1P2 complex from Mycobacterium tuberculosis, revealing an asymmetric architecture and selective activator binding. They show that molecular crowding promotes assembly and activation of Clp complexes, suggesting a mechanism for ClpP1P2 activation under physiological conditions.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-241126","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241126","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241126"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241126\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241126"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241126"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}