{"id":241087,"date":"2026-07-17T12:20:29","date_gmt":"2026-07-17T17:20:29","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/feasibility-evaluation-of-tumor-treating-fields-for-brainstem-gliomas"},"modified":"2026-07-17T12:20:29","modified_gmt":"2026-07-17T17:20:29","slug":"feasibility-evaluation-of-tumor-treating-fields-for-brainstem-gliomas","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/feasibility-evaluation-of-tumor-treating-fields-for-brainstem-gliomas","title":{"rendered":"Feasibility evaluation of tumor treating fields for brainstem gliomas"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/feasibility-evaluation-of-tumor-treating-fields-for-brainstem-gliomas.jpg\"><\/a><\/p>\n<p>Tumor treating fields (TTFields) are FDA-approved for supratentorial glioblastoma, but feasibility in infratentorial tumors remains poorly defined. This simulation study evaluated TTFields dose in brainstem gliomas using patient-specific modeling with scalp-only transducer arrays.<\/p>\n<p>MRI and CT imaging from seven patients with brainstem gliomas were used for TTFields planning with MAXPOINT<sup>\u00ae<\/sup> (Novocure, Switzerland). Clinical target volume (CTV) was defined as enhancing tumor on T1 post-contrast MRI (Gross tumor volume, GTV) plus a 3 mm peritumoral expansion. The platform optimized scalp-only array layouts, and finite element calculations generated maps of local minimum field intensity (LMiFI, V\/cm) and local minimum power density (LMiPD, mW\/cm\u00b3). Values were compared against a standard, unplanned layout using one-sided paired t-tests, with LMiFI \u2265 1.0 V\/cm as a therapeutic reference.<\/p>\n<p>MAXPOINT-optimized layouts achieved significantly higher LMiFI than the standard layout across all regions (all p \u2264 0.019). GTV median LMiFI was 1.1 vs. 1.0 V\/cm (p = 0.019). CTV median LMiFI was 1.1 vs. 1.0 V\/cm (p = 0.002). Brainstem median LMiFI was 1.3 vs. 1.1 V\/cm (p = 0.002). Posterior fossa showed the largest difference: median LMiFI 1.5 vs. 1.2 V\/cm (p 0.001). All optimized LMiFI values met or exceeded the therapeutic reference. LMiPD was also significantly higher with MAXPOINT<sup>\u00ae<\/sup> across all regions (all p \u2264 0.006).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tumor treating fields (TTFields) are FDA-approved for supratentorial glioblastoma, but feasibility in infratentorial tumors remains poorly defined. This simulation study evaluated TTFields dose in brainstem gliomas using patient-specific modeling with scalp-only transducer arrays. MRI and CT imaging from seven patients with brainstem gliomas were used for TTFields planning with MAXPOINT\u00ae (Novocure, Switzerland). Clinical target volume [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-241087","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241087"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241087\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}