{"id":241085,"date":"2026-07-17T12:19:56","date_gmt":"2026-07-17T17:19:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/decoding-of-amidated-aromatic-cterminus-and-sulfation-by-cholecystokinin-receptors-reveals-conserved-and-divergent-evolutionary-mechanisms"},"modified":"2026-07-17T12:19:56","modified_gmt":"2026-07-17T17:19:56","slug":"decoding-of-amidated-aromatic-cterminus-and-sulfation-by-cholecystokinin-receptors-reveals-conserved-and-divergent-evolutionary-mechanisms","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/decoding-of-amidated-aromatic-cterminus-and-sulfation-by-cholecystokinin-receptors-reveals-conserved-and-divergent-evolutionary-mechanisms","title":{"rendered":"Decoding of amidated aromatic Cterminus and sulfation by cholecystokinin receptors reveals conserved and divergent evolutionary mechanisms"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/decoding-of-amidated-aromatic-cterminus-and-sulfation-by-cholecystokinin-receptors-reveals-conserved-and-divergent-evolutionary-mechanisms3.jpg\"><\/a><\/p>\n<p>Understanding how evolutionarily related receptors preserve recognition principles for conserved peptide post-translational modifications (PTMs) while acquiring new selectivity remains central to neuropeptide-G protein-coupled receptor (GPCR) biology. The <i>Aplysia<\/i> cholecystokinin (CCK) system provides an informative model, as its peptides combine two representative PTM-related features: an amidated aromatic C-terminus (RFamide\/DFamide), and a dual-tyrosine sulfation pattern exceeding the single-site architecture typical of vertebrates.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Understanding how evolutionarily related receptors preserve recognition principles for conserved peptide post-translational modifications (PTMs) while acquiring new selectivity remains central to neuropeptide-G protein-coupled receptor (GPCR) biology. The Aplysia cholecystokinin (CCK) system provides an informative model, as its peptides combine two representative PTM-related features: an amidated aromatic C-terminus (RFamide\/DFamide), and a dual-tyrosine sulfation pattern exceeding the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-241085","post","type-post","status-publish","format-standard","hentry","category-biological"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=241085"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/241085\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=241085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=241085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=241085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}