{"id":240568,"date":"2026-07-10T00:14:39","date_gmt":"2026-07-10T05:14:39","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/safety-tolerability-and-metabolic-effects-of-long-acting-cabotegravir-and-rilpivirine-in-hiv-care-a-comprehensive-review"},"modified":"2026-07-10T00:14:39","modified_gmt":"2026-07-10T05:14:39","slug":"safety-tolerability-and-metabolic-effects-of-long-acting-cabotegravir-and-rilpivirine-in-hiv-care-a-comprehensive-review","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/safety-tolerability-and-metabolic-effects-of-long-acting-cabotegravir-and-rilpivirine-in-hiv-care-a-comprehensive-review","title":{"rendered":"Safety, Tolerability, and Metabolic Effects of Long-Acting Cabotegravir and Rilpivirine in HIV Care: A Comprehensive Review"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/safety-tolerability-and-metabolic-effects-of-long-acting-cabotegravir-and-rilpivirine-in-hiv-care-a-comprehensive-review.jpg\"><\/a><\/p>\n<p>The use of long-acting cabotegravir and rilpivirine (LA CAB\/RPV) is a novel approach to manage human immunodeficiency virus (HIV). This injectable regimen offers benefits such as an improved quality of life, reduced stigma and enhanced treatment satisfaction by minimising the need for daily medication adherence. This review summarises the findings of clinical trials and real-world studies on the safety, tolerability and metabolic effects of LA CAB\/RPV, which are areas that have received less extensive coverage in previous reviews. Clinical trial data suggest that LA CAB\/RPV is generally safe and well tolerated. The most common side effects were injection site reactions, affecting 70\u201397% of participants. However, these were typically mild and short lived, rarely leading to treatment discontinuation in fewer than 2\u20133% of cases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The use of long-acting cabotegravir and rilpivirine (LA CAB\/RPV) is a novel approach to manage human immunodeficiency virus (HIV). This injectable regimen offers benefits such as an improved quality of life, reduced stigma and enhanced treatment satisfaction by minimising the need for daily medication adherence. This review summarises the findings of clinical trials and real-world [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-240568","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/240568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=240568"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/240568\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=240568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=240568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=240568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}