{"id":240419,"date":"2026-07-07T07:29:55","date_gmt":"2026-07-07T12:29:55","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/dysregulated-calcium-signaling-underlies-hyposalivation-and-microbial-dysbiosis-in-down-syndrome"},"modified":"2026-07-07T07:29:55","modified_gmt":"2026-07-07T12:29:55","slug":"dysregulated-calcium-signaling-underlies-hyposalivation-and-microbial-dysbiosis-in-down-syndrome","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/dysregulated-calcium-signaling-underlies-hyposalivation-and-microbial-dysbiosis-in-down-syndrome","title":{"rendered":"Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/dysregulated-calcium-signaling-underlies-hyposalivation-and-microbial-dysbiosis-in-down-syndrome2.jpg\"><\/a><\/p>\n<p>People with Down syndrome (DS) show reduced saliva flow and high periodontal disease burden. In Dp16 mice, a model of DS, Son et al. show that deficient calcium signaling in salivary glands underlies hyposalivation and is associated with oral and gut microbial dysbiosis and altered succinate levels.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>People with Down syndrome (DS) show reduced saliva flow and high periodontal disease burden. In Dp16 mice, a model of DS, Son et al. show that deficient calcium signaling in salivary glands underlies hyposalivation and is associated with oral and gut microbial dysbiosis and altered succinate levels.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-240419","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/240419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=240419"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/240419\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=240419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=240419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=240419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}