{"id":240305,"date":"2026-07-05T00:17:43","date_gmt":"2026-07-05T05:17:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/resilience-to-autosomal-dominant-alzheimers-disease-in-a-reelin-colbos-heterozygous-man"},"modified":"2026-07-05T00:17:43","modified_gmt":"2026-07-05T05:17:43","slug":"resilience-to-autosomal-dominant-alzheimers-disease-in-a-reelin-colbos-heterozygous-man","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/resilience-to-autosomal-dominant-alzheimers-disease-in-a-reelin-colbos-heterozygous-man","title":{"rendered":"Resilience to autosomal dominant Alzheimer\u2019s disease in a Reelin-COLBOS heterozygous man"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/resilience-to-autosomal-dominant-alzheimers-disease-in-a-reelin-colbos-heterozygous-man.jpg\"><\/a><\/p>\n<p>Fascinating case study on the neuroprotective effects of a mutant reelin allele (<i>RELN\u2013<i>COLBOS<\/i><\/i>) which delayed disease progression in a patient with autosomal dominant Alzheimer\u2019s disease (ADAD). A promising therapeutic target!<\/p>\n<hr>\n<p>Case report of an individual heterozygous for a rare <i>RELN\u2013<i>COLBOS<\/i><\/i> variant that confers resilience, via a gain-of-function mechanism, to Alzheimer\u2019s disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fascinating case study on the neuroprotective effects of a mutant reelin allele (RELN\u2013COLBOS) which delayed disease progression in a patient with autosomal dominant Alzheimer\u2019s disease (ADAD). A promising therapeutic target! Case report of an individual heterozygous for a rare RELN\u2013COLBOS variant that confers resilience, via a gain-of-function mechanism, to Alzheimer\u2019s disease.<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-240305","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/240305","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=240305"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/240305\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=240305"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=240305"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=240305"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}