{"id":240085,"date":"2026-07-01T07:35:51","date_gmt":"2026-07-01T12:35:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/07\/aars1-promotes-tumor-progression-and-immune-evasion-via-atf6-lactylation-mediated-tryptophan-metabolism-in-hepatocellular-carcinoma"},"modified":"2026-07-01T07:35:51","modified_gmt":"2026-07-01T12:35:51","slug":"aars1-promotes-tumor-progression-and-immune-evasion-via-atf6-lactylation-mediated-tryptophan-metabolism-in-hepatocellular-carcinoma","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/07\/aars1-promotes-tumor-progression-and-immune-evasion-via-atf6-lactylation-mediated-tryptophan-metabolism-in-hepatocellular-carcinoma","title":{"rendered":"AARS1 promotes tumor progression and immune evasion via ATF6 lactylation-mediated tryptophan metabolism in hepatocellular carcinoma"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/aars1-promotes-tumor-progression-and-immune-evasion-via-atf6-lactylation-mediated-tryptophan-metabolism-in-hepatocellular-carcinoma.jpg\"><\/a><\/p>\n<p>Wang et al. identify a metabolic-immune feedback circuit in hepatocellular carcinoma, in which tumor cell-intrinsic AARS1-mediated ATF6 lactylation activates the TDO2-kynurenine axis to promote Treg differentiation and immunosuppression, while Treg-derived eNAMPT enhances tumor glycolysis and lactate production, revealing a therapeutic vulnerability to AARS1 inhibition combined with PD-1\/PD-L1 blockade.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wang et al. identify a metabolic-immune feedback circuit in hepatocellular carcinoma, in which tumor cell-intrinsic AARS1-mediated ATF6 lactylation activates the TDO2-kynurenine axis to promote Treg differentiation and immunosuppression, while Treg-derived eNAMPT enhances tumor glycolysis and lactate production, revealing a therapeutic vulnerability to AARS1 inhibition combined with PD-1\/PD-L1 blockade.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-240085","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/240085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=240085"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/240085\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=240085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=240085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=240085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}