{"id":240042,"date":"2026-06-30T22:12:10","date_gmt":"2026-07-01T03:12:10","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/06\/rethinking-mrna-vaccines-liver-targeting-can-suppress-immunity-while-muscle-boosts-it"},"modified":"2026-06-30T22:12:10","modified_gmt":"2026-07-01T03:12:10","slug":"rethinking-mrna-vaccines-liver-targeting-can-suppress-immunity-while-muscle-boosts-it","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/06\/rethinking-mrna-vaccines-liver-targeting-can-suppress-immunity-while-muscle-boosts-it","title":{"rendered":"Rethinking mRNA vaccines: Liver targeting can suppress immunity, while muscle boosts it"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/rethinking-mrna-vaccines-liver-targeting-can-suppress-immunity-while-muscle-boosts-it.jpg\"><\/a><\/p>\n<p>A new study by researchers at the Icahn School of Medicine at Mount Sinai overturns a longstanding assumption about how mRNA vaccines generate immunity, revealing that certain non-immune cells help determine vaccine effectiveness.<\/p>\n<p>The study, published in <a href=\"https:\/\/www.nature.com\/articles\/s41587-026-03099-z\" target=\"_blank\"><i>Nature Biotechnology<\/i><\/a>, also introduces a powerful and versatile technology to control the expression of mRNA drugs, which the researchers demonstrate can enhance the effectiveness of mRNA cancer vaccines in preclinical studies of lymphoma. The paper is titled \u201cmRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell expression.\u201d<\/p>\n<p>The findings provide a new framework for designing mRNA vaccines and mRNA therapeutics, with immediate implications for cancer immunotherapy, infectious disease vaccines, and gene-editing treatments.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study by researchers at the Icahn School of Medicine at Mount Sinai overturns a longstanding assumption about how mRNA vaccines generate immunity, revealing that certain non-immune cells help determine vaccine effectiveness. The study, published in Nature Biotechnology, also introduces a powerful and versatile technology to control the expression of mRNA drugs, which the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-240042","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/240042","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=240042"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/240042\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=240042"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=240042"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=240042"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}