{"id":240022,"date":"2026-06-30T14:14:10","date_gmt":"2026-06-30T19:14:10","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/06\/long-term-outcomes-and-late-effects-of-surgery-and-radiotherapy-in-adult-intracranial-ependymoma-patients"},"modified":"2026-06-30T14:14:10","modified_gmt":"2026-06-30T19:14:10","slug":"long-term-outcomes-and-late-effects-of-surgery-and-radiotherapy-in-adult-intracranial-ependymoma-patients","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/06\/long-term-outcomes-and-late-effects-of-surgery-and-radiotherapy-in-adult-intracranial-ependymoma-patients","title":{"rendered":"Long-term outcomes and late effects of surgery and radiotherapy in adult intracranial ependymoma patients"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/long-term-outcomes-and-late-effects-of-surgery-and-radiotherapy-in-adult-intracranial-ependymoma-patients.jpg\"><\/a><\/p>\n<p>To evaluate progression-free survival (PFS), overall survival (OS), local control (LC), and radiotherapy-related toxicities in the treatment of adult intracranial ependymoma.<\/p>\n<p>A retrospective analysis was performed of WHO grade 2\u20133 adult intracranial ependymoma patients (\u2265 18 years) treated with surgery alone or surgery and adjuvant radiotherapy between 2000 and 2024. Kaplan-Meier analyses were used to estimate PFS and OS. Acute and late treatment-related toxicities were characterized.<\/p>\n<p>Fifty-eight patients met the inclusion criteria. Median age was 39 years (interquartile range [IQR] 25\u201351), and median follow-up was 51 months (IQR 23\u2013103). Overall, 76% were WHO grade 2, 74% had posterior fossa location, gross total resection was achieved in 60%, 88% received adjuvant local radiotherapy, and 5% received adjuvant chemotherapy. Five and 10-year PFS rates were 80% and 64%, respectively; 5 and 10-year OS rates were 92% and 85%, respectively. There were 13 (22%) recurrences: The location of first failure was local in nine, distant in two, and both local and distant in two. The 5-year LC rate was 82% (95% CI 67\u201390%), and the 10-year LC rate was 72% (95% CI 53\u201384%). The median time to local failure was 5.4 years. Ten (22%) patients experienced at least one grade \u2265 2 late treatment-related toxicity. One potential secondary glioma (grade 5) occurred after nine years.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>To evaluate progression-free survival (PFS), overall survival (OS), local control (LC), and radiotherapy-related toxicities in the treatment of adult intracranial ependymoma. A retrospective analysis was performed of WHO grade 2\u20133 adult intracranial ependymoma patients (\u2265 18 years) treated with surgery alone or surgery and adjuvant radiotherapy between 2000 and 2024. Kaplan-Meier analyses were used to [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-240022","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/240022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=240022"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/240022\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=240022"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=240022"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=240022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}