{"id":239858,"date":"2026-06-28T07:21:19","date_gmt":"2026-06-28T12:21:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/06\/scientists-uncover-a-genetic-shield-that-lowers-the-risk-of-colorectal-cancer"},"modified":"2026-06-28T07:21:19","modified_gmt":"2026-06-28T12:21:19","slug":"scientists-uncover-a-genetic-shield-that-lowers-the-risk-of-colorectal-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/06\/scientists-uncover-a-genetic-shield-that-lowers-the-risk-of-colorectal-cancer","title":{"rendered":"Scientists uncover a genetic \u2018shield\u2019 that lowers the risk of colorectal cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-uncover-a-genetic-shield-that-lowers-the-risk-of-colorectal-cancer.jpg\"><\/a><\/p>\n<p>A team of scientists from the Barbara Ann Karmanos Cancer Institute, Wayne State University and institutions across the U.S. have published a new paper on the role of <i><i>TGFBR1<\/i>*<\/i>6A, a naturally occurring genetic mutation in the <i>TGFBR1<\/i> gene found in approximately 14% of the general population.<\/p>\n<p>The study, \u201c<i><i>TGFBR1<\/i>*<\/i>6A and risk for colorectal cancer,\u201d <a href=\"https:\/\/spj.science.org\/doi\/10.34133\/cancomm.0033\" target=\"_blank\">published<\/a> June 9, 2026, in <i>Cancer Communications<\/i>, focuses on <i><i>TGFBR1<\/i>*<\/i>6A and how it influences a person\u2019s risk of developing colorectal cancer. Dr. Boris Pasche, president and CEO of the Karmanos Cancer Institute and chair of the Wayne State University Department of Oncology, was the first to discover <i><i>TGFBR1<\/i>*<\/i>6A as a cancer risk allele.<\/p>\n<p>\u201cThis mutation has often been overlooked by genome-wide association study chips, which cannot detect <i><i>TGFBR1<\/i>*<\/i>6A, and is commonly missed by next-generation sequencing platforms due to the complexity of the region,\u201d said Dr. Allan Johansen, a postdoctoral fellow and first author of the paper.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of scientists from the Barbara Ann Karmanos Cancer Institute, Wayne State University and institutions across the U.S. have published a new paper on the role of TGFBR1*6A, a naturally occurring genetic mutation in the TGFBR1 gene found in approximately 14% of the general population. The study, \u201cTGFBR1*6A and risk for colorectal cancer,\u201d published [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1523,412],"tags":[],"class_list":["post-239858","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-computing","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/239858","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=239858"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/239858\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=239858"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=239858"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=239858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}