{"id":239816,"date":"2026-06-27T19:20:04","date_gmt":"2026-06-28T00:20:04","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/06\/high-resolution-mapping-of-ccr4-not-recruitment-elements-reveals-transcriptome-wide-drivers-of-mrna-decay"},"modified":"2026-06-27T19:20:04","modified_gmt":"2026-06-28T00:20:04","slug":"high-resolution-mapping-of-ccr4-not-recruitment-elements-reveals-transcriptome-wide-drivers-of-mrna-decay","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/06\/high-resolution-mapping-of-ccr4-not-recruitment-elements-reveals-transcriptome-wide-drivers-of-mrna-decay","title":{"rendered":"High-resolution mapping of CCR4-NOT recruitment elements reveals transcriptome-wide drivers of mRNA decay"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/high-resolution-mapping-of-ccr4-not-recruitment-elements-reveals-transcriptome-wide-drivers-of-mrna-decay2.jpg\"><\/a><\/p>\n<p>Luo et al. present TRACER, a transcriptome-wide approach to identify RNA elements that recruit the CCR4-NOT complex. TRACER uncovers thousands of CCR4-NOT-associated elements, many mapping to known or predicted RBP and miRNA target sites. These elements drive mRNA repression and can be targeted using gene editing or ASO approaches.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Luo et al. present TRACER, a transcriptome-wide approach to identify RNA elements that recruit the CCR4-NOT complex. TRACER uncovers thousands of CCR4-NOT-associated elements, many mapping to known or predicted RBP and miRNA target sites. These elements drive mRNA repression and can be targeted using gene editing or ASO approaches.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-239816","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/239816","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=239816"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/239816\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=239816"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=239816"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=239816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}