{"id":239711,"date":"2026-06-26T10:29:59","date_gmt":"2026-06-26T15:29:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/06\/tp53-based-tripartite-classification-reveals-three-distinct-mutation-patterns-across-pan-cancer"},"modified":"2026-06-26T10:29:59","modified_gmt":"2026-06-26T15:29:59","slug":"tp53-based-tripartite-classification-reveals-three-distinct-mutation-patterns-across-pan-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/06\/tp53-based-tripartite-classification-reveals-three-distinct-mutation-patterns-across-pan-cancer","title":{"rendered":"TP53-based tripartite classification reveals three distinct mutation patterns across pan-cancer"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/tp53-based-tripartite-classification-reveals-three-distinct-mutation-patterns-across-pan-cancer2.jpg\"><\/a><\/p>\n<p>Ma et al. present a pan-cancer analysis of 61 cancers that defines a TP53-based tripartite classification: TP53_top, TP53_plus, and Non_TP53. Analysis of 80,524 mutations and network integration reveals mutational heterogeneity, dysregulated transcription factor regulatory networks, and signaling pathway networks, providing a framework for precision oncology.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ma et al. present a pan-cancer analysis of 61 cancers that defines a TP53-based tripartite classification: TP53_top, TP53_plus, and Non_TP53. Analysis of 80,524 mutations and network integration reveals mutational heterogeneity, dysregulated transcription factor regulatory networks, and signaling pathway networks, providing a framework for precision oncology.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-239711","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/239711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=239711"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/239711\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=239711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=239711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=239711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}