{"id":239282,"date":"2026-06-18T22:13:00","date_gmt":"2026-06-19T03:13:00","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/06\/the-apoe-r136s-mutation-protects-against-apoe4-driven-tau-pathology-neurodegeneration-and-neuroinflammation"},"modified":"2026-06-18T22:13:00","modified_gmt":"2026-06-19T03:13:00","slug":"the-apoe-r136s-mutation-protects-against-apoe4-driven-tau-pathology-neurodegeneration-and-neuroinflammation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/06\/the-apoe-r136s-mutation-protects-against-apoe4-driven-tau-pathology-neurodegeneration-and-neuroinflammation","title":{"rendered":"The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-apoe-r136s-mutation-protects-against-apoe4-driven-tau-pathology-neurodegeneration-and-neuroinflammation.jpg\"><\/a><\/p>\n<p>Nelson <i>et al.<\/i> present a detailed biomolecular study of how the APOE-R136S mutation protects against Alzheimer\u2019s disease (AD) in mice and in patient-derived cells. Lots of data on glial contributions and transcriptomic changes. I see this as an excellent target for gene therapies aiming to combat AD. So do the folks at Lexeo Therapeutics (an exciting company you should check out!) <\/p>\n<hr>\n<p>Nelson <i>et al.<\/i> report that the APOE-R136S mutation protects against APOE4-promoted Alzheimer\u2019s disease pathologies, including phosphorylated Tau accumulation, neuroinflammation and neurodegeneration, in mouse and human neuron models.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nelson et al. present a detailed biomolecular study of how the APOE-R136S mutation protects against Alzheimer\u2019s disease (AD) in mice and in patient-derived cells. Lots of data on glial contributions and transcriptomic changes. I see this as an excellent target for gene therapies aiming to combat AD. So do the folks at Lexeo Therapeutics (an [\u2026]<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-239282","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/239282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=239282"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/239282\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=239282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=239282"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=239282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}