{"id":239062,"date":"2026-06-16T07:28:18","date_gmt":"2026-06-16T12:28:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/06\/bacteria-reveal-glue-protein-that-fastens-antibiotic-resistant-outer-membrane-to-cell-wall"},"modified":"2026-06-16T07:28:18","modified_gmt":"2026-06-16T12:28:18","slug":"bacteria-reveal-glue-protein-that-fastens-antibiotic-resistant-outer-membrane-to-cell-wall","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/06\/bacteria-reveal-glue-protein-that-fastens-antibiotic-resistant-outer-membrane-to-cell-wall","title":{"rendered":"Bacteria reveal \u2018glue\u2019 protein that fastens antibiotic-resistant outer membrane to cell wall"},"content":{"rendered":"

<\/a><\/p>\n

Researchers at the University of Notre Dame and collaborators have discovered a key process in how the outer membrane of gram-negative bacteria attaches to the cell wall, advancing the understanding of how these bacteria frequently develop resistance to antibiotics.<\/p>\n

The research<\/a>, published in the Journal of the American Chemical Society<\/i>, was carried out in the laboratory of Shahriar Mobashery, Navari Professor of Life Sciences in the Department of Chemistry and Biochemistry, with structural aspects of the study performed by Juan A. Hermoso of the Institute of Physical Chemistry \u201cBlas Cabrera\u201d in Madrid, Spain. The researchers discovered that the protein PA2854 performs the reaction that keeps the outside layers, or envelope, of gram-negative bacteria connected to each other.<\/p>\n

Mobashery and collaborators studied the process in Pseudomonas aeruginosa<\/i> (P. aeruginosa), a ubiquitous antibiotic-resistant bacterium commonly affecting people with cystic fibrosis. P. aeruginosa, like other gram-negative bacteria including E. coli, Klebsiella pneumoniae and Salmonella, is shielded by a three-layer biological envelope that prevents many antibiotics from penetrating and damaging the bacteria. Gram-positive bacteria do not have an outer membrane and are generally more susceptible to antibiotics.<\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers at the University of Notre Dame and collaborators have discovered a key process in how the outer membrane of gram-negative bacteria attaches to the cell wall, advancing the understanding of how these bacteria frequently develop resistance to antibiotics. The research, published in the Journal of the American Chemical Society, was carried out in the [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19],"tags":[],"class_list":["post-239062","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/239062","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=239062"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/239062\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=239062"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=239062"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=239062"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}