{"id":238390,"date":"2026-06-05T02:18:43","date_gmt":"2026-06-05T07:18:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/06\/novel-synthetic-biomolecule-degrades-disease-related-proteins"},"modified":"2026-06-05T02:18:43","modified_gmt":"2026-06-05T07:18:43","slug":"novel-synthetic-biomolecule-degrades-disease-related-proteins","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/06\/novel-synthetic-biomolecule-degrades-disease-related-proteins","title":{"rendered":"Novel synthetic biomolecule degrades disease-related proteins"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/novel-synthetic-biomolecule-degrades-disease-related-proteins2.jpg\"><\/a><\/p>\n<p>Northwestern Medicine scientists have developed a novel synthetic biomolecular condensate that can degrade intracellular disease-causing proteins, providing a framework for new therapeutic approaches for a wide range of diseases, as detailed in a recent study <a href=\"https:\/\/www.nature.com\/articles\/s41467-026-72967-8\" target=\"_blank\">published<\/a> in <i>Nature Communications.<\/i><\/p>\n<p>Shana Kelley, Ph.D., the Neena B. Schwartz Professor of Chemistry, Biomedical Engineering, and Biochemistry and Molecular Genetics and the president of the Chan Zuckerberg Biohub Chicago, was senior author of the study.<\/p>\n<p><a href=\"https:\/\/phys.org\/news\/2024-03-scientists-generate-protein-degradation-tunes.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal\" rel=\"related\">Targeted protein degradation<\/a> is an emerging therapeutic strategy that harnesses cells\u2019 own degradation machinery to clear disease-causing proteins. However, achieving this degradation process across different cell types has remained a challenge due to subtle variations in protein structure.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Northwestern Medicine scientists have developed a novel synthetic biomolecular condensate that can degrade intracellular disease-causing proteins, providing a framework for new therapeutic approaches for a wide range of diseases, as detailed in a recent study published in Nature Communications. Shana Kelley, Ph.D., the Neena B. Schwartz Professor of Chemistry, Biomedical Engineering, and Biochemistry and Molecular [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,19,412],"tags":[],"class_list":["post-238390","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-chemistry","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/238390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=238390"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/238390\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=238390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=238390"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=238390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}