{"id":238288,"date":"2026-06-03T22:14:13","date_gmt":"2026-06-04T03:14:13","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/06\/ai-misses-cancer-drug-target-revealing-why-lab-validation-still-matters"},"modified":"2026-06-03T22:14:13","modified_gmt":"2026-06-04T03:14:13","slug":"ai-misses-cancer-drug-target-revealing-why-lab-validation-still-matters","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/06\/ai-misses-cancer-drug-target-revealing-why-lab-validation-still-matters","title":{"rendered":"AI misses cancer drug target, revealing why lab validation still matters"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ai-misses-cancer-drug-target-revealing-why-lab-validation-still-matters.jpg\"><\/a><\/p>\n<p>Researchers at the Icahn School of Medicine at Mount Sinai have identified a previously hidden druggable site in a cancer-related protein that could open the door toward the development of a new generation of more precise cancer drugs. The finding also reveals important limitations in today\u2019s artificial intelligence tools for drug discovery.<\/p>\n<p>The study, <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.6c05178\" target=\"_blank\">published<\/a> in the June 2 online issue of the <i>Journal of the American Chemical Society<\/i>, focused on <a href=\"https:\/\/medicalxpress.com\/news\/2024-05-pkmyt1-potential-achilles-heel-treatment.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal\" rel=\"related\">PKMYT1<\/a>, a type of protein known as a kinase that helps control how cells grow and divide. Because this process can go wrong in cancer, PKMYT1 has emerged as a promising target for new cancer drugs.<\/p>\n<p>Most experimental drugs designed to block kinases work by targeting a region called the ATP-binding site\u2014the part of the protein that uses the cell\u2019s energy supply to function. But many kinases share nearly identical ATP-binding sites, making it difficult for drugs to distinguish between the desired target and other kinases, which can lead to unwanted side effects.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the Icahn School of Medicine at Mount Sinai have identified a previously hidden druggable site in a cancer-related protein that could open the door toward the development of a new generation of more precise cancer drugs. The finding also reveals important limitations in today\u2019s artificial intelligence tools for drug discovery. The study, published [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,6],"tags":[],"class_list":["post-238288","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/238288","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=238288"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/238288\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=238288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=238288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=238288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}