{"id":238262,"date":"2026-06-03T14:07:08","date_gmt":"2026-06-03T19:07:08","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/06\/neuroproteasomes-regulate-endogenous-tau-paired-helical-filament-formation-in-an-apoe-genotype-and-age-dependent-manner"},"modified":"2026-06-03T14:07:08","modified_gmt":"2026-06-03T19:07:08","slug":"neuroproteasomes-regulate-endogenous-tau-paired-helical-filament-formation-in-an-apoe-genotype-and-age-dependent-manner","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/06\/neuroproteasomes-regulate-endogenous-tau-paired-helical-filament-formation-in-an-apoe-genotype-and-age-dependent-manner","title":{"rendered":"Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/neuroproteasomes-regulate-endogenous-tau-paired-helical-filament-formation-in-an-apoe-genotype-and-age-dependent-manner.jpg\"><\/a><\/p>\n<p>A cellular explanation for how tau aggregates into fibrils in Alzheimer\u2019s disease has been elusive. This paper identifies the failure of \u2018neuroproteasomes\u2019 as sufficient to convert tau into paired helical filaments, a process regulated by ApoE and aging.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A cellular explanation for how tau aggregates into fibrils in Alzheimer\u2019s disease has been elusive. This paper identifies the failure of \u2018neuroproteasomes\u2019 as sufficient to convert tau into paired helical filaments, a process regulated by ApoE and aging.<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-238262","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/238262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=238262"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/238262\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=238262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=238262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=238262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}