{"id":238235,"date":"2026-06-03T02:30:14","date_gmt":"2026-06-03T07:30:14","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/06\/deep-brain-stimulation-boosts-myelination-and-shifts-brain-networks-linked-to-depression"},"modified":"2026-06-03T02:30:14","modified_gmt":"2026-06-03T07:30:14","slug":"deep-brain-stimulation-boosts-myelination-and-shifts-brain-networks-linked-to-depression","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/06\/deep-brain-stimulation-boosts-myelination-and-shifts-brain-networks-linked-to-depression","title":{"rendered":"Deep brain stimulation boosts myelination and shifts brain networks linked to depression"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/deep-brain-stimulation-boosts-myelination-and-shifts-brain-networks-linked-to-depression2.jpg\"><\/a><\/p>\n<p>Researchers from the Icahn School of Medicine at Mount Sinai have uncovered the first direct evidence that deep brain stimulation (DBS) can remodel white matter pathways in the brain and alter communication across large-scale neural networks, revealing a previously unrecognized mechanism that may explain how the therapy helps patients recover from severe depression. The study, <a href=\"https:\/\/www.nature.com\/articles\/s41593-026-02301-4\" target=\"_blank\">published<\/a> June 1 in <i>Nature Neuroscience<\/i>, provides critical insight into the biological basis of DBS, an emerging therapy for treatment-resistant depression and other neuropsychiatric disorders.<\/p>\n<p>Deep brain stimulation, approved by the U.S. Food and Drug Administration to treat essential tremor, Parkinson\u2019s disease, epilepsy, and obsessive-compulsive disorder, is a neurosurgical procedure involving placement of a neurostimulator (sometimes referred to as a \u201cbrain pacemaker\u201d), which sends high-frequency electrical impulses through implanted electrodes deep in the brain to specific areas responsible for the symptoms of each disorder.<\/p>\n<p>Although DBS has shown sustained clinical benefit for many patients with severe depression who do not respond to medications, psychotherapy, and electroconvulsive therapy, the mechanisms underlying its therapeutic effects have remained poorly understood.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from the Icahn School of Medicine at Mount Sinai have uncovered the first direct evidence that deep brain stimulation (DBS) can remodel white matter pathways in the brain and alter communication across large-scale neural networks, revealing a previously unrecognized mechanism that may explain how the therapy helps patients recover from severe depression. The study, [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,6],"tags":[],"class_list":["post-238235","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/238235","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=238235"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/238235\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=238235"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=238235"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=238235"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}