{"id":238186,"date":"2026-06-02T06:17:53","date_gmt":"2026-06-02T11:17:53","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/06\/why-some-tumors-resist-immunotherapy-blocking-mir-25-may-help-turn-cold-cancers-hot"},"modified":"2026-06-02T06:17:53","modified_gmt":"2026-06-02T11:17:53","slug":"why-some-tumors-resist-immunotherapy-blocking-mir-25-may-help-turn-cold-cancers-hot","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/06\/why-some-tumors-resist-immunotherapy-blocking-mir-25-may-help-turn-cold-cancers-hot","title":{"rendered":"Why some tumors resist immunotherapy: Blocking miR-25 may help turn \u2018cold\u2019 cancers \u2018hot\u2019"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/why-some-tumors-resist-immunotherapy-blocking-mir-25-may-help-turn-cold-cancers-hot.jpg\"><\/a><\/p>\n<p>Immune checkpoint therapy, a type of cancer immunotherapy that helps the immune system recognize and attack tumors, has transformed cancer treatment. While these therapies can produce long-lasting benefits for some patients, many cancers either fail to respond or become resistant over time.<\/p>\n<p>One major challenge is the <a href=\"https:\/\/medicalxpress.com\/news\/2023-01-keys-immunotherapy-pancreatic-cancer-tumor.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal\" rel=\"related\">tumor microenvironment <\/a>\u2014the network of cells and signals surrounding tumors that can weaken immune cells and protect cancer from treatment. This protective environment can act like a shield that prevents immunotherapy from working effectively.<\/p>\n<p>Researchers at University of California San Diego investigated whether <a href=\"https:\/\/medicalxpress.com\/news\/2024-09-pathway-biomarkers-immune-checkpoint-inhibitors.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal\" rel=\"related\">microRNAs <\/a>\u2014small RNA molecules that help control gene activity\u2014play a role in creating this treatment-resistant environment. The team focused on microRNA-25 (miR-25), which stood out after analyses showed that its levels changed in tumors that responded to immunotherapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Immune checkpoint therapy, a type of cancer immunotherapy that helps the immune system recognize and attack tumors, has transformed cancer treatment. While these therapies can produce long-lasting benefits for some patients, many cancers either fail to respond or become resistant over time. One major challenge is the tumor microenvironment \u2014the network of cells and signals [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-238186","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/238186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=238186"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/238186\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=238186"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=238186"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=238186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}