{"id":238056,"date":"2026-05-30T19:04:58","date_gmt":"2026-05-31T00:04:58","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/legend-scientific-founder-returns-to-asco-with-new-ambition-for-high-yield-non-gene-editing-car-t-platform"},"modified":"2026-05-30T19:04:58","modified_gmt":"2026-05-31T00:04:58","slug":"legend-scientific-founder-returns-to-asco-with-new-ambition-for-high-yield-non-gene-editing-car-t-platform","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/legend-scientific-founder-returns-to-asco-with-new-ambition-for-high-yield-non-gene-editing-car-t-platform","title":{"rendered":"Legend scientific founder returns to ASCO with new ambition for high-yield, non-gene-editing CAR-T platform"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/legend-scientific-founder-returns-to-asco-with-new-ambition-for-high-yield-non-gene-editing-car-t-platform.jpg\"><\/a><\/p>\n<p>Nine years after <a href=\"https:\/\/www.fiercebiotech.com\/biotech\/asco-dark-horse-nanjing-legend-biotech-shines-promising-car-t-data\">wowing<\/a> the audience at the American Society of Clinical Oncology annual meeting with a CAR-T candidate that would become Carvykti\u2014now the world\u2019s most successful cell therapy\u2014Legend Biotech\u2019s scientific founder, Frank Fan, M.D., Ph.D., is returning to the spotlight with an entirely new playbook.<\/p>\n<p>This time, Fan isn\u2019t showcasing an autologous product engineered with each individual patient\u2019s cells. Instead, with his new venture, Wondercel Therapeutics, Fan hopes an off-the-shelf universal CAR-T platform can tackle two bottlenecks of the cell therapy industry: massive production scalability and<strong> <\/strong>the pitfalls associated with gene editing.<\/p>\n<p>\u201cIf this approach proves successful, the critical thing is that we can achieve linear scalability in CAR-T production capacity that can match traditional biologics,\u201d Fan said in an interview with Fierce.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nine years after wowing the audience at the American Society of Clinical Oncology annual meeting with a CAR-T candidate that would become Carvykti\u2014now the world\u2019s most successful cell therapy\u2014Legend Biotech\u2019s scientific founder, Frank Fan, M.D., Ph.D., is returning to the spotlight with an entirely new playbook. This time, Fan isn\u2019t showcasing an autologous product engineered [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-238056","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/238056","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=238056"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/238056\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=238056"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=238056"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=238056"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}