{"id":237845,"date":"2026-05-27T23:07:51","date_gmt":"2026-05-28T04:07:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/structural-plasticity-of-the-membrane-bound-protein-degradation-assembly-supports-bacterial-adaptation-to-stress"},"modified":"2026-05-27T23:07:51","modified_gmt":"2026-05-28T04:07:51","slug":"structural-plasticity-of-the-membrane-bound-protein-degradation-assembly-supports-bacterial-adaptation-to-stress","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/structural-plasticity-of-the-membrane-bound-protein-degradation-assembly-supports-bacterial-adaptation-to-stress","title":{"rendered":"Structural plasticity of the membrane-bound protein degradation assembly supports bacterial adaptation to stress"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/structural-plasticity-of-the-membrane-bound-protein-degradation-assembly-supports-bacterial-adaptation-to-stress2.jpg\"><\/a><\/p>\n<p>Iqbal et al. show that HflK\/C conformational dynamics regulate bacterial adaptation to aminoglycoside stress. Using disulfide crosslinking to constrain the closed state, they demonstrate that stabilizing a closed HflK\/C assembly impairs stress recovery and reveal a stress-induced conformation with dual openings that may facilitate FtsH-dependent membrane proteolysis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Iqbal et al. show that HflK\/C conformational dynamics regulate bacterial adaptation to aminoglycoside stress. Using disulfide crosslinking to constrain the closed state, they demonstrate that stabilizing a closed HflK\/C assembly impairs stress recovery and reveal a stress-induced conformation with dual openings that may facilitate FtsH-dependent membrane proteolysis.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-237845","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237845","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=237845"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237845\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=237845"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=237845"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=237845"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}