{"id":237811,"date":"2026-05-27T03:24:35","date_gmt":"2026-05-27T08:24:35","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/single-step-8-9x-expansion-reveals-nanoscale-centrioles-without-electron-microscopy"},"modified":"2026-05-27T03:24:35","modified_gmt":"2026-05-27T08:24:35","slug":"single-step-8-9x-expansion-reveals-nanoscale-centrioles-without-electron-microscopy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/single-step-8-9x-expansion-reveals-nanoscale-centrioles-without-electron-microscopy","title":{"rendered":"Single-step 8-9x expansion reveals nanoscale centrioles without electron microscopy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/single-step-8-9x-expansion-reveals-nanoscale-centrioles-without-electron-microscopy2.jpg\"><\/a><\/p>\n<p>In a study <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.6c05501\" target=\"_blank\">published<\/a> in <i>ACS Nano<\/i>, researchers from National Taiwan University report a new expansion microscopy strategy termed high-fold homogeneous expansion microscopy (hiHomoExM), capable of achieving approximately 8\u20139\u00d7 isotropic expansion in a single expansion step while preserving delicate ultrastructural organization.<\/p>\n<p>Expansion microscopy works by embedding biological samples within a <a href=\"https:\/\/phys.org\/news\/2022-08-microscopy-technique-reveals-hidden-nanostructures.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal\" rel=\"related\">swellable polymer hydrogel<\/a>. Following chemical processing, the hydrogel expands uniformly in water, physically separating biomolecules and effectively increasing the spatial resolution achievable by conventional light microscopes.<\/p>\n<p>\u201cTo achieve nanoscale imaging faithfully, both high expansion and homogeneous specimen preservation are essential,\u201d explains the research team. \u201cNonuniform expansion can distort ultrastructural information and limit biological interpretation.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a study published in ACS Nano, researchers from National Taiwan University report a new expansion microscopy strategy termed high-fold homogeneous expansion microscopy (hiHomoExM), capable of achieving approximately 8\u20139\u00d7 isotropic expansion in a single expansion step while preserving delicate ultrastructural organization. Expansion microscopy works by embedding biological samples within a swellable polymer hydrogel. Following chemical [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,19,4],"tags":[],"class_list":["post-237811","post","type-post","status-publish","format-standard","hentry","category-biological","category-chemistry","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=237811"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237811\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=237811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=237811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=237811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}