{"id":237707,"date":"2026-05-25T18:10:20","date_gmt":"2026-05-25T23:10:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/naturally-self-reactive-b-cells-are-poised-to-cross-the-selection-barrier-into-autoimmune-germinal-centers"},"modified":"2026-05-25T18:10:20","modified_gmt":"2026-05-25T23:10:20","slug":"naturally-self-reactive-b-cells-are-poised-to-cross-the-selection-barrier-into-autoimmune-germinal-centers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/naturally-self-reactive-b-cells-are-poised-to-cross-the-selection-barrier-into-autoimmune-germinal-centers","title":{"rendered":"Naturally self-reactive B cells are poised to cross the selection barrier into autoimmune germinal centers"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/naturally-self-reactive-b-cells-are-poised-to-cross-the-selection-barrier-into-autoimmune-germinal-centers2.jpg\"><\/a><\/p>\n<p>Circulating B cells often react to self-antigen, but whether this predisposes for autoimmunity is unclear. Using a mouse model of lupus erythematosus, Zhu et al. demonstrate that human B cells displaying naturally autoreactive immunoglobulin sequences are advantaged for retention when immune tolerance is broken.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Circulating B cells often react to self-antigen, but whether this predisposes for autoimmunity is unclear. Using a mouse model of lupus erythematosus, Zhu et al. demonstrate that human B cells displaying naturally autoreactive immunoglobulin sequences are advantaged for retention when immune tolerance is broken.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-237707","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237707","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=237707"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237707\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=237707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=237707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=237707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}