{"id":237659,"date":"2026-05-23T18:11:14","date_gmt":"2026-05-23T23:11:14","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/capsidas-trailblazing-moment-what-the-field-owes-the-next-bbb-program"},"modified":"2026-05-23T18:11:14","modified_gmt":"2026-05-23T23:11:14","slug":"capsidas-trailblazing-moment-what-the-field-owes-the-next-bbb-program","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/capsidas-trailblazing-moment-what-the-field-owes-the-next-bbb-program","title":{"rendered":"Capsida\u2019s Trailblazing Moment: What the Field Owes the Next BBB Program"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/capsidas-trailblazing-moment-what-the-field-owes-the-next-bbb-program.jpg\"><\/a><\/p>\n<p>An insightful perspective on what biological factors may have been the cause of a patient\u2019s death after receiving a blood-brain-barrier crossing AAV treatment. It\u2019s crucial for the field to think about this carefully as we move forward.<\/p>\n<hr>\n<p>\n<a href=\"https:\/\/www.thebiomlclinic.com\/\" target=\"_blank\">TheBioMLClinic<\/a><\/p>\n<p><b><\/b><b><\/b><b>Brief disclosure:<\/b> I am a named inventor on patents and author on publications related to AAV capsid engineering and CNS gene delivery, developed during my time at the Broad Institute. I now operate independently. This post does not represent any prior employer, current advisory client, or collaborator. The mechanistic analysis presented here is my own scientific interpretation of publicly available data. Full disclosures at the bottom.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An insightful perspective on what biological factors may have been the cause of a patient\u2019s death after receiving a blood-brain-barrier crossing AAV treatment. It\u2019s crucial for the field to think about this carefully as we move forward. TheBioMLClinic Brief disclosure: I am a named inventor on patents and author on publications related to AAV capsid [\u2026]<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,38,47],"tags":[],"class_list":["post-237659","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-engineering","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237659","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=237659"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237659\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=237659"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=237659"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=237659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}