{"id":237546,"date":"2026-05-21T22:03:05","date_gmt":"2026-05-22T03:03:05","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/how-schizophrenia-risk-may-begin-gene-changes-reshape-signaling-in-developing-neurons"},"modified":"2026-05-21T22:03:05","modified_gmt":"2026-05-22T03:03:05","slug":"how-schizophrenia-risk-may-begin-gene-changes-reshape-signaling-in-developing-neurons","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/how-schizophrenia-risk-may-begin-gene-changes-reshape-signaling-in-developing-neurons","title":{"rendered":"How schizophrenia risk may begin: Gene changes reshape signaling in developing neurons"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/how-schizophrenia-risk-may-begin-gene-changes-reshape-signaling-in-developing-neurons3.jpg\"><\/a><\/p>\n<p>Researchers at King\u2019s College London have identified the biological nature and timing of changes in human cortical neurons caused by altering activity of a schizophrenia-associated gene in developing human neurons. This discovery links a genetic risk factor to cellular changes in neurons; an essential step for understanding the neurobiology of this mental illness and developing future treatments.<\/p>\n<p>Schizophrenia is estimated to be one of the most heritable psychiatric conditions, with a strong developmental aspect. Large-scale human genomic studies have identified many genetic variants which are thought to increase the likelihood of schizophrenia.<\/p>\n<p>However, the link between these genetic risk variants and the underlying neurobiology of schizophrenia is less well understood. Addressing this knowledge gap provides vital information that could ultimately help develop therapies for the disorder.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at King\u2019s College London have identified the biological nature and timing of changes in human cortical neurons caused by altering activity of a schizophrenia-associated gene in developing human neurons. This discovery links a genetic risk factor to cellular changes in neurons; an essential step for understanding the neurobiology of this mental illness and developing [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,412,47],"tags":[],"class_list":["post-237546","post","type-post","status-publish","format-standard","hentry","category-biological","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237546","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=237546"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237546\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=237546"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=237546"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=237546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}