{"id":237408,"date":"2026-05-19T19:14:27","date_gmt":"2026-05-20T00:14:27","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/hypoxia-induced-autophagic-degradation-of-hif-1%ce%b1-attenuates-cellular-aging-and-extends-mammalian-lifespan"},"modified":"2026-05-19T19:14:27","modified_gmt":"2026-05-20T00:14:27","slug":"hypoxia-induced-autophagic-degradation-of-hif-1%ce%b1-attenuates-cellular-aging-and-extends-mammalian-lifespan","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/hypoxia-induced-autophagic-degradation-of-hif-1%ce%b1-attenuates-cellular-aging-and-extends-mammalian-lifespan","title":{"rendered":"Hypoxia-induced autophagic degradation of HIF-1\u03b1 attenuates cellular aging and extends mammalian lifespan"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/hypoxia-induced-autophagic-degradation-of-hif-1ceb1-attenuates-cellular-aging-and-extends-mammalian-lifespan.jpg\"><\/a><\/p>\n<p>Emerging evidence suggests that organs age at different rates. This study identifies a mechanism by which the naturally hypoxic intervertebral disc ages relatively slowly, via selective autophagy of HIF-1\u03b1, and designs a small molecule to export this mechanism across tissues.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Emerging evidence suggests that organs age at different rates. This study identifies a mechanism by which the naturally hypoxic intervertebral disc ages relatively slowly, via selective autophagy of HIF-1\u03b1, and designs a small molecule to export this mechanism across tissues.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-237408","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237408","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=237408"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237408\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=237408"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=237408"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=237408"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}