{"id":237288,"date":"2026-05-16T18:17:25","date_gmt":"2026-05-16T23:17:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/metabolism-by-ex-vivo-cultures-of-human-stool-increases-the-activity-of-coumarin-a-widespread-antioxidant-from-herbal-supplements"},"modified":"2026-05-16T18:17:25","modified_gmt":"2026-05-16T23:17:25","slug":"metabolism-by-ex-vivo-cultures-of-human-stool-increases-the-activity-of-coumarin-a-widespread-antioxidant-from-herbal-supplements","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/metabolism-by-ex-vivo-cultures-of-human-stool-increases-the-activity-of-coumarin-a-widespread-antioxidant-from-herbal-supplements","title":{"rendered":"Metabolism by ex vivo cultures of human stool increases the activity of coumarin, a widespread antioxidant from herbal supplements"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/metabolism-by-ex-vivo-cultures-of-human-stool-increases-the-activity-of-coumarin-a-widespread-antioxidant-from-herbal-supplements2.jpg\"><\/a><\/p>\n<p>Mingolelli et al. characterize microbiome metabolism of coumarin in ex vivo cultures from human stool. Seventeen gut species reduce coumarin to 3,4-dihydrocoumarin and melilotic acid, including <i>E. coli<\/i>, through an N-ethylmaleimide-reductase-dependent pathway. Gut metabolites demonstrate increased antioxidant activity compared to either coumarin or its host metabolite, umbelliferone.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mingolelli et al. characterize microbiome metabolism of coumarin in ex vivo cultures from human stool. Seventeen gut species reduce coumarin to 3,4-dihydrocoumarin and melilotic acid, including E. coli, through an N-ethylmaleimide-reductase-dependent pathway. Gut metabolites demonstrate increased antioxidant activity compared to either coumarin or its host metabolite, umbelliferone.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-237288","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237288","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=237288"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237288\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=237288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=237288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=237288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}