{"id":237221,"date":"2026-05-15T18:09:00","date_gmt":"2026-05-15T23:09:00","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/fisetin-attenuates-d-gal-induced-ovarian-aging-by-modulating-mitophagy-via-the-ampk-mtor-pathway"},"modified":"2026-05-15T18:09:00","modified_gmt":"2026-05-15T23:09:00","slug":"fisetin-attenuates-d-gal-induced-ovarian-aging-by-modulating-mitophagy-via-the-ampk-mtor-pathway","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/fisetin-attenuates-d-gal-induced-ovarian-aging-by-modulating-mitophagy-via-the-ampk-mtor-pathway","title":{"rendered":"Fisetin Attenuates D-Gal-Induced Ovarian Aging by Modulating Mitophagy via the AMPK\/mTOR Pathway"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/fisetin-attenuates-d-gal-induced-ovarian-aging-by-modulating-mitophagy-via-the-ampk-mtor-pathway.jpg\"><\/a><\/p>\n<p>This study aimed to explore the alleviating effects of fisetin, a polyphenolic flavonoid, on ovarian dysfunction in a D-galactose (D-gal)-induced aging mouse model, as well as the underlying mechanisms, using both in vivo and in vitro experiments. Mice were subcutaneously injected with D-gal (100 mg\/kg\/day) for 60 days to establish the ovarian aging model; during the final 30 days, fisetin (10, 20, 30 mg\/kg\/day) was given orally. In addition, a senescent model of granulosa cell (GC) was established using D-gal and treated with fisetin. Fisetin supplementation improved ovarian endocrine function and reproductive capacity in aging mice, as reflected by regularized estrous cycles, elevated estradiol levels, and increased embryo numbers.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This study aimed to explore the alleviating effects of fisetin, a polyphenolic flavonoid, on ovarian dysfunction in a D-galactose (D-gal)-induced aging mouse model, as well as the underlying mechanisms, using both in vivo and in vitro experiments. Mice were subcutaneously injected with D-gal (100 mg\/kg\/day) for 60 days to establish the ovarian aging model; during [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269],"tags":[],"class_list":["post-237221","post","type-post","status-publish","format-standard","hentry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237221","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=237221"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237221\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=237221"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=237221"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=237221"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}