{"id":237154,"date":"2026-05-14T14:22:03","date_gmt":"2026-05-14T19:22:03","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/4-octyl-itaconate-inhibits-cytokine-mediated-inflammation-via-alkylation-of-tyk2-and-jak1"},"modified":"2026-05-14T14:22:03","modified_gmt":"2026-05-14T19:22:03","slug":"4-octyl-itaconate-inhibits-cytokine-mediated-inflammation-via-alkylation-of-tyk2-and-jak1","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/4-octyl-itaconate-inhibits-cytokine-mediated-inflammation-via-alkylation-of-tyk2-and-jak1","title":{"rendered":"4-octyl itaconate inhibits cytokine-mediated inflammation via alkylation of TYK2 and JAK1"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/4-octyl-itaconate-inhibits-cytokine-mediated-inflammation-via-alkylation-of-tyk2-and-jak12.jpg\"><\/a><\/p>\n<p>Li et al. discovered that 4-octyl itaconate (4-OI) directly covalently modifies TYK2 and JAK1 to inhibit the type I interferon response. Endogenous metabolite itaconate in sepsis is a JAK inhibitor. In the mouse, <i>in vivo<\/i> experiments, intraperitoneal injection of 4-octyl itaconate could alleviate multi-organ damage caused by sepsis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Li et al. discovered that 4-octyl itaconate (4-OI) directly covalently modifies TYK2 and JAK1 to inhibit the type I interferon response. Endogenous metabolite itaconate in sepsis is a JAK inhibitor. In the mouse, in vivo experiments, intraperitoneal injection of 4-octyl itaconate could alleviate multi-organ damage caused by sepsis.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-237154","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=237154"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237154\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=237154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=237154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=237154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}