{"id":237046,"date":"2026-05-13T03:20:59","date_gmt":"2026-05-13T08:20:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/regulation-of-neuronal-invasion-of-small-cell-lung-cancer-by-stmn2-%ce%b2-alanine-controlled-metabolic-reprogramming"},"modified":"2026-05-13T03:20:59","modified_gmt":"2026-05-13T08:20:59","slug":"regulation-of-neuronal-invasion-of-small-cell-lung-cancer-by-stmn2-%ce%b2-alanine-controlled-metabolic-reprogramming","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/regulation-of-neuronal-invasion-of-small-cell-lung-cancer-by-stmn2-%ce%b2-alanine-controlled-metabolic-reprogramming","title":{"rendered":"Regulation of neuronal invasion of small cell lung cancer by STMN2\/\u03b2-alanine-controlled metabolic reprogramming"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/regulation-of-neuronal-invasion-of-small-cell-lung-cancer-by-stmn2-ceb2-alanine-controlled-metabolic-reprogramming.jpg\"><\/a><\/p>\n<p>Zhou et al. demonstrate that perineural invasion (PNI) is an adverse prognostic factor in small cell lung cancer. They identify a neuron-STMN2-\u03b2-alanine axis, where the neural microenvironment upregulates STMN2 in tumor cells, reprogramming \u03b2-alanine metabolism to enhance cell migration and drive neural invasion, revealing a potential therapeutic target.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zhou et al. demonstrate that perineural invasion (PNI) is an adverse prognostic factor in small cell lung cancer. They identify a neuron-STMN2-\u03b2-alanine axis, where the neural microenvironment upregulates STMN2 in tumor cells, reprogramming \u03b2-alanine metabolism to enhance cell migration and drive neural invasion, revealing a potential therapeutic target.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-237046","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237046","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=237046"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237046\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=237046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=237046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=237046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}