{"id":237043,"date":"2026-05-13T03:16:53","date_gmt":"2026-05-13T08:16:53","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/gut-microbiota-derived-deoxycholic-acid-shapes-an-immunosuppressive-tumor-microenvironment-and-promotes-breast-cancer-progression"},"modified":"2026-05-13T03:16:53","modified_gmt":"2026-05-13T08:16:53","slug":"gut-microbiota-derived-deoxycholic-acid-shapes-an-immunosuppressive-tumor-microenvironment-and-promotes-breast-cancer-progression","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/gut-microbiota-derived-deoxycholic-acid-shapes-an-immunosuppressive-tumor-microenvironment-and-promotes-breast-cancer-progression","title":{"rendered":"Gut microbiota-derived deoxycholic acid shapes an immunosuppressive tumor microenvironment and promotes breast cancer progression"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/gut-microbiota-derived-deoxycholic-acid-shapes-an-immunosuppressive-tumor-microenvironment-and-promotes-breast-cancer-progression2.jpg\"><\/a><\/p>\n<p>Li et al. identify deoxycholic acid as a microbiota-derived driver of breast cancer progression. Deoxycholic acid activates farnesoid X receptor signaling to induce interleukin-6 production, promoting immunosuppressive cell recruitment and establishing a metabolite-driven immune regulatory axis with therapeutic potential.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Li et al. identify deoxycholic acid as a microbiota-derived driver of breast cancer progression. Deoxycholic acid activates farnesoid X receptor signaling to induce interleukin-6 production, promoting immunosuppressive cell recruitment and establishing a metabolite-driven immune regulatory axis with therapeutic potential.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-237043","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237043","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=237043"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/237043\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=237043"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=237043"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=237043"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}