{"id":236911,"date":"2026-05-11T15:16:30","date_gmt":"2026-05-11T20:16:30","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/regulatory-derived-tgf-%ce%b2-signaling-governs-the-differentiation-and-maintenance-of-tumor-infiltrating-bystander-cd8-t-cells"},"modified":"2026-05-11T15:16:30","modified_gmt":"2026-05-11T20:16:30","slug":"regulatory-derived-tgf-%ce%b2-signaling-governs-the-differentiation-and-maintenance-of-tumor-infiltrating-bystander-cd8-t-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/regulatory-derived-tgf-%ce%b2-signaling-governs-the-differentiation-and-maintenance-of-tumor-infiltrating-bystander-cd8-t-cells","title":{"rendered":"Regulatory derived TGF-\u03b2 signaling governs the differentiation and maintenance of tumor-infiltrating bystander CD8+ T cells"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/regulatory-derived-tgf-ceb2-signaling-governs-the-differentiation-and-maintenance-of-tumor-infiltrating-bystander-cd8-t-cells.jpg\"><\/a><\/p>\n<p>Lin et al. reveal that tumor-infiltrating bystander CD8+ T cells are heterogeneous and undergo a TCM-to-TEM-to-TRM differentiation trajectory driven by Treg-derived TGF-\u03b2 signaling through suppression of KLF2. This mechanism sustains bystander CD8+ T cell heterogeneity and accumulation in tumors and provides a targetable mechanism for cancer immunotherapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lin et al. reveal that tumor-infiltrating bystander CD8+ T cells are heterogeneous and undergo a TCM-to-TEM-to-TRM differentiation trajectory driven by Treg-derived TGF-\u03b2 signaling through suppression of KLF2. This mechanism sustains bystander CD8+ T cell heterogeneity and accumulation in tumors and provides a targetable mechanism for cancer immunotherapy.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-236911","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236911","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236911"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236911\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236911"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236911"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236911"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}