{"id":236830,"date":"2026-05-09T06:54:44","date_gmt":"2026-05-09T11:54:44","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/a-blood-brain-barrier-like-vascular-gate-limits-immunotherapy-efficacy-in-neuroendocrine-cancers"},"modified":"2026-05-09T06:54:44","modified_gmt":"2026-05-09T11:54:44","slug":"a-blood-brain-barrier-like-vascular-gate-limits-immunotherapy-efficacy-in-neuroendocrine-cancers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/a-blood-brain-barrier-like-vascular-gate-limits-immunotherapy-efficacy-in-neuroendocrine-cancers","title":{"rendered":"A blood-brain barrier-like vascular gate limits immunotherapy efficacy in neuroendocrine cancers"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-blood-brain-barrier-like-vascular-gate-limits-immunotherapy-efficacy-in-neuroendocrine-cancers2.jpg\"><\/a><\/p>\n<p>A blood-brain barrier-like vascular gate in small cell lung cancer and other neuroendocrine cancers blocks immune cells and drives resistance to immunotherapy. Targeting the proteins IGF1R or <i>IGFBP5<\/i> boosts CD8+ T cell infiltration and enhances anti-PD1 therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A blood-brain barrier-like vascular gate in small cell lung cancer and other neuroendocrine cancers blocks immune cells and drives resistance to immunotherapy. Targeting the proteins IGF1R or IGFBP5 boosts CD8+ T cell infiltration and enhances anti-PD1 therapy.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-236830","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236830","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236830"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236830\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236830"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236830"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236830"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}