{"id":236446,"date":"2026-05-03T22:22:55","date_gmt":"2026-05-04T03:22:55","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/genetic-variation-reveals-a-homeotic-long-noncoding-rna-that-modulates-human-hematopoietic-stem-cells"},"modified":"2026-05-03T22:22:55","modified_gmt":"2026-05-04T03:22:55","slug":"genetic-variation-reveals-a-homeotic-long-noncoding-rna-that-modulates-human-hematopoietic-stem-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/genetic-variation-reveals-a-homeotic-long-noncoding-rna-that-modulates-human-hematopoietic-stem-cells","title":{"rendered":"Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/genetic-variation-reveals-a-homeotic-long-noncoding-rna-that-modulates-human-hematopoietic-stem-cells.jpg\"><\/a><\/p>\n<p>A blood cancer-protective inherited variant in the homeotic lncRNA <i>HOTSCRAMBL<\/i> alters HOXA9 splicing, fine-tuning hematopoietic stem cell self-renewal while constraining HOXA-driven blood cancers.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A blood cancer-protective inherited variant in the homeotic lncRNA HOTSCRAMBL alters HOXA9 splicing, fine-tuning hematopoietic stem cell self-renewal while constraining HOXA-driven blood cancers.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-236446","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236446","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236446"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236446\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236446"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236446"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236446"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}