{"id":236445,"date":"2026-05-03T22:16:29","date_gmt":"2026-05-04T03:16:29","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/human-dna-pkcs-promotes-broken-dna-end-structure-independence-during-nhej"},"modified":"2026-05-03T22:16:29","modified_gmt":"2026-05-04T03:16:29","slug":"human-dna-pkcs-promotes-broken-dna-end-structure-independence-during-nhej","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/human-dna-pkcs-promotes-broken-dna-end-structure-independence-during-nhej","title":{"rendered":"Human DNA-PKcs promotes broken DNA-end structure independence during NHEJ"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/human-dna-pkcs-promotes-broken-dna-end-structure-independence-during-nhej2.jpg\"><\/a><\/p>\n<p>Whether DNA-PKcs is necessary for non-homologous end joining has been biochemically obscure. Through optimization of reaction conditions, Fujii and Modesti show that DNA-PKcs plays a constructive role, which leads to indistinguishable repair efficiencies between cohesive-end and blunt-end DNA substrates.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Whether DNA-PKcs is necessary for non-homologous end joining has been biochemically obscure. Through optimization of reaction conditions, Fujii and Modesti show that DNA-PKcs plays a constructive role, which leads to indistinguishable repair efficiencies between cohesive-end and blunt-end DNA substrates.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19],"tags":[],"class_list":["post-236445","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236445"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236445\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236445"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236445"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}