{"id":236370,"date":"2026-05-02T11:11:51","date_gmt":"2026-05-02T16:11:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/cdk1-dependent-n-terminal-numa-phosphorylation-promotes-dynein-dynactin-numa-assembly-for-accurate-chromosome-segregation"},"modified":"2026-05-02T11:11:51","modified_gmt":"2026-05-02T16:11:51","slug":"cdk1-dependent-n-terminal-numa-phosphorylation-promotes-dynein-dynactin-numa-assembly-for-accurate-chromosome-segregation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/cdk1-dependent-n-terminal-numa-phosphorylation-promotes-dynein-dynactin-numa-assembly-for-accurate-chromosome-segregation","title":{"rendered":"CDK1-dependent N-terminal NuMA phosphorylation promotes dynein-dynactin-NuMA assembly for accurate chromosome segregation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cdk1-dependent-n-terminal-numa-phosphorylation-promotes-dynein-dynactin-numa-assembly-for-accurate-chromosome-segregation2.jpg\"><\/a><\/p>\n<p>Van Toorn et al. show that CDK1-mediated phosphorylation of NuMA at serine 203 promotes stable dynein-dynactin-NuMA assembly in human cells. This mitotic phosphorylation thereby contributes to robust spindle formation and accurate chromosome segregation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Van Toorn et al. show that CDK1-mediated phosphorylation of NuMA at serine 203 promotes stable dynein-dynactin-NuMA assembly in human cells. This mitotic phosphorylation thereby contributes to robust spindle formation and accurate chromosome segregation.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-236370","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236370","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236370"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236370\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236370"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236370"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236370"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}