{"id":236358,"date":"2026-05-01T22:32:10","date_gmt":"2026-05-02T03:32:10","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/an-intrinsically-disordered-tug-of-war-that-fine-tunes-acetylation"},"modified":"2026-05-01T22:32:10","modified_gmt":"2026-05-02T03:32:10","slug":"an-intrinsically-disordered-tug-of-war-that-fine-tunes-acetylation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/an-intrinsically-disordered-tug-of-war-that-fine-tunes-acetylation","title":{"rendered":"An intrinsically disordered tug of war that fine-tunes acetylation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/an-intrinsically-disordered-tug-of-war-that-fine-tunes-acetylation2.jpg\"><\/a><\/p>\n<p>Acetylation of histones and transcriptional regulators modulates gene expression, but how acetyltransferases define target specificity remains puzzling. In <i>Cell Reports<\/i>, Gelder et al. have shown how intrinsically disordered regions of CBP temper each other to shape acetyltransferase activity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Acetylation of histones and transcriptional regulators modulates gene expression, but how acetyltransferases define target specificity remains puzzling. In Cell Reports, Gelder et al. have shown how intrinsically disordered regions of CBP temper each other to shape acetyltransferase activity.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-236358","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236358"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236358\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236358"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236358"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}