{"id":236296,"date":"2026-05-01T06:17:04","date_gmt":"2026-05-01T11:17:04","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/05\/abstract-slc26a4-gene-mutations-are-a-frequent-cause-of-hereditary-hearingloss"},"modified":"2026-05-01T06:17:04","modified_gmt":"2026-05-01T11:17:04","slug":"abstract-slc26a4-gene-mutations-are-a-frequent-cause-of-hereditary-hearingloss","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/05\/abstract-slc26a4-gene-mutations-are-a-frequent-cause-of-hereditary-hearingloss","title":{"rendered":"Abstract: SLC26A4-gene mutations are a frequent cause of hereditary HearingLoss"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract135.jpg\"><\/a><\/p>\n<p><i><i>SLC26A4<\/i>-<\/i>gene mutations are a frequent cause of hereditary HearingLoss.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1172\/JCI193812\">https:\/\/doi.org\/10.1172\/JCI193812<\/a> Here, Tsai et al. report that targeted AAV delivery to the endolymphatic sac and cochlear lateral wall restores auditory physiology and ameliorates cochlear pathology in a mouse model of <i>Slc26a4<\/i>-related deafness. Pendred syndrome DFNB4.<\/p>\n<p>The image shows an AAV-GFP\u2013transduced spiral prominence, a structure within the cochlear lateral wall. GFP (green) marks successfully transduced cells, phalloidin-568 (red) labels the actin cytoskeleton, and DAPI (blue) stains nuclei, highlighting efficient gene transfer to inner ear tissues essential for auditory function.<\/p>\n<hr>\n<p>Address correspondence to: Chen-Chi Wu, Department of Otolaryngology, National Taiwan University Hospital, No. 1, Changde St., Zhongzheng Dist., Taipei City 100,229, Taiwan. Phone: 886.2.2312.3456; Email: <a href=\"mailto:chenchiwu@ntuh.gov.tw\">chenchiwu@ntuh.gov.tw<\/a>. Or to: Yen-Fu Cheng, Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei City 11,217, Taiwan. Phone: 886.2.2875.7642; Email: <a href=\"mailto:yfcheng2@vghtpe.gov.tw\">yfcheng2@vghtpe.gov.tw<\/a>.<\/p>\n<p>Find articles by Tsai, Y. in: <a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=search&db=pubmed&term=Tsai+Y[au>&dispmax=50\"]PubMed<\/a> | <a target=\"_blank\" href=\"https:\/\/scholar.google.com\/scholar?q=%22author%3AY+Tsai%22\">Google Scholar<\/a><\/p>\n<p><sup>1<\/sup>Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/05\/abstract-slc26a4-gene-mutations-are-a-frequent-cause-of-hereditary-hearingloss\">Continue reading \u201cAbstract: SLC26A4-gene mutations are a frequent cause of hereditary HearingLoss\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>SLC26A4-gene mutations are a frequent cause of hereditary HearingLoss. https:\/\/doi.org\/10.1172\/JCI193812 Here, Tsai et al. report that targeted AAV delivery to the endolymphatic sac and cochlear lateral wall restores auditory physiology and ameliorates cochlear pathology in a mouse model of Slc26a4-related deafness. Pendred syndrome DFNB4. The image shows an AAV-GFP\u2013transduced spiral prominence, a structure within the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1512],"tags":[],"class_list":["post-236296","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-mobile-phones"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236296","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236296"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236296\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236296"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236296"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}