{"id":236234,"date":"2026-04-30T15:15:07","date_gmt":"2026-04-30T20:15:07","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/spatial-transcriptomics-from-pancreas-and-local-draining-lymph-node-tissue-reveals-a-lymphotoxin-%ce%b2-signature-in-human-type-1-diabetes"},"modified":"2026-04-30T15:15:07","modified_gmt":"2026-04-30T20:15:07","slug":"spatial-transcriptomics-from-pancreas-and-local-draining-lymph-node-tissue-reveals-a-lymphotoxin-%ce%b2-signature-in-human-type-1-diabetes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/spatial-transcriptomics-from-pancreas-and-local-draining-lymph-node-tissue-reveals-a-lymphotoxin-%ce%b2-signature-in-human-type-1-diabetes","title":{"rendered":"Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-\u03b2 signature in human type 1 diabetes"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/spatial-transcriptomics-from-pancreas-and-local-draining-lymph-node-tissue-reveals-a-lymphotoxin-ceb2-signature-in-human-type-1-diabetes2.jpg\"><\/a><\/p>\n<p>Medina-Serpas et al. provide a public spatial transcriptomic atlas of pancreas and pLN comprising defined stages of human T1D. Cross-platform validation revealed pancreatic inflammation and elevated lymphotoxin-\u03b2 expression as a signature of T1D, persistent across tissues. These data support therapeutic targeting of the lymphotoxin\/TNF pathway in T1D.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Medina-Serpas et al. provide a public spatial transcriptomic atlas of pancreas and pLN comprising defined stages of human T1D. Cross-platform validation revealed pancreatic inflammation and elevated lymphotoxin-\u03b2 expression as a signature of T1D, persistent across tissues. These data support therapeutic targeting of the lymphotoxin\/TNF pathway in T1D.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-236234","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236234"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236234\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}