{"id":236202,"date":"2026-04-30T02:19:29","date_gmt":"2026-04-30T07:19:29","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/new-genome-editing-method-could-swap-entire-genes-and-correct-1000-mutations-at-once"},"modified":"2026-04-30T02:19:29","modified_gmt":"2026-04-30T07:19:29","slug":"new-genome-editing-method-could-swap-entire-genes-and-correct-1000-mutations-at-once","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/new-genome-editing-method-could-swap-entire-genes-and-correct-1000-mutations-at-once","title":{"rendered":"New genome editing method could swap entire genes and correct 1000 mutations at once"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-genome-editing-method-could-swap-entire-genes-and-correct-1000-mutations-at-once2.jpg\"><\/a><\/p>\n<p>New technology enables the insertion of a large segment of DNA into a genome, potentially expanding gene therapy treatment from cancellation of disease-causing mutations to replacement of an entire gene, scientists say.<\/p>\n<p>Reporting in <a href=\"https:\/\/www.nature.com\/articles\/s41586-026-10460-4\" target=\"_blank\"><i>Nature<\/i><\/a>, the researchers describe building upon a technique called <a href=\"https:\/\/www.nature.com\/articles\/s12276-025-01463-8\" target=\"_blank\">prime editing<\/a> by inserting DNA that attaches to the genome through a series of <a href=\"https:\/\/phys.org\/news\/2024-05-elucidate-spatial-molecular-mechanisms-prime.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal\" rel=\"related\">overlapping flaps<\/a>. This method, which they call a prime assembly approach, avoids a bottleneck in the gene therapy field\u2014a double-strand break to the donor DNA that can cause toxicity and kill cells.<\/p>\n<p>\u201cUsing this method, we are doing genome assembly rather than making a small edit in a gene,\u201d said Bin Liu, a co-lead author of the study and assistant professor of biological chemistry and pharmacology at The Ohio State University College of Medicine. \u201cIf we think of the genome as a book, we can remove one paragraph and replace it with a new one\u2014or even rewrite a chapter.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New technology enables the insertion of a large segment of DNA into a genome, potentially expanding gene therapy treatment from cancellation of disease-causing mutations to replacement of an entire gene, scientists say. Reporting in Nature, the researchers describe building upon a technique called prime editing by inserting DNA that attaches to the genome through a [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-236202","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236202","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236202"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236202\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236202"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236202"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}