{"id":236174,"date":"2026-04-29T22:08:46","date_gmt":"2026-04-30T03:08:46","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/a-popular-senolytic-treatment-causes-brain-damage-in-mice"},"modified":"2026-04-29T22:08:46","modified_gmt":"2026-04-30T03:08:46","slug":"a-popular-senolytic-treatment-causes-brain-damage-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/a-popular-senolytic-treatment-causes-brain-damage-in-mice","title":{"rendered":"A Popular Senolytic Treatment Causes Brain Damage in Mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-popular-senolytic-treatment-causes-brain-damage-in-mice.jpg\"><\/a><\/p>\n<p>A new study calls for caution in using the well-known senolytic treatment of dasatinib and quercetin (D+Q), showing that it <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41843680\/\">causes damage in certain regions of the brain<\/a>, similar to what is observed in multiple sclerosis [1].<\/p>\n<p><b><b>Stem cell senescence prevents brain repair<\/b><\/b><\/p>\n<p>Multiple sclerosis (MS) is a brain disorder in which the patient\u2019s own immune system attacks oligodendrocytes: cells in the nervous system that provide a myelin coating for neurons, which is essential for their function and survival. MS is much more common in older patients, who are also more likely to have progressive disease and a worse response to treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study calls for caution in using the well-known senolytic treatment of dasatinib and quercetin (D+Q), showing that it causes damage in certain regions of the brain, similar to what is observed in multiple sclerosis [1]. Stem cell senescence prevents brain repair Multiple sclerosis (MS) is a brain disorder in which the patient\u2019s own [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-236174","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236174"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236174\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}