{"id":236146,"date":"2026-04-29T10:10:06","date_gmt":"2026-04-29T15:10:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/loss-of-microbiota-alters-the-profile-of-cells-that-protect-the-intestinal-wall-experiments-reveal"},"modified":"2026-04-29T10:10:06","modified_gmt":"2026-04-29T15:10:06","slug":"loss-of-microbiota-alters-the-profile-of-cells-that-protect-the-intestinal-wall-experiments-reveal","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/loss-of-microbiota-alters-the-profile-of-cells-that-protect-the-intestinal-wall-experiments-reveal","title":{"rendered":"Loss of microbiota alters the profile of cells that protect the intestinal wall, experiments reveal"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/loss-of-microbiota-alters-the-profile-of-cells-that-protect-the-intestinal-wall-experiments-reveal2.jpg\"><\/a><\/p>\n<p>A research team led by scientists from the State University of Campinas (UNICAMP) in S\u00e3o Paulo, Brazil, has made significant progress in understanding the relationship between gut microbiota and intestinal cells. The study, published in the journal Gut Microbes, showed how microbiota and the compounds it produces, such as butyrate, influence the functioning of cells that line the large intestine. This intestinal layer is in close contact with bacteria and produces mucus that contributes to its barrier function, helping to prevent bacteria from entering the body.<\/p>\n<p>Among the findings is a description of the dual function of a cell that was previously thought to be exclusively mucus-secreting. The researchers discovered that the cell also absorbs nutrients and that its abundance in the epithelium is regulated by signals from the gut microbiota. The number of these cells increases when the gut microbiota is reduced.<\/p>\n<p>The abundance of this cell is regulated by the production of butyrate\u2014a compound resulting from the fermentation of dietary fiber\u2014and its receptor, GPR109A. The more butyrate produced, the fewer of these cells there are.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A research team led by scientists from the State University of Campinas (UNICAMP) in S\u00e3o Paulo, Brazil, has made significant progress in understanding the relationship between gut microbiota and intestinal cells. The study, published in the journal Gut Microbes, showed how microbiota and the compounds it produces, such as butyrate, influence the functioning of cells [\u2026]<\/p>\n","protected":false},"author":707,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-236146","post","type-post","status-publish","format-standard","hentry","category-biological"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/707"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236146"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236146\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}