{"id":236108,"date":"2026-04-29T03:11:37","date_gmt":"2026-04-29T08:11:37","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/caveolin-1-deficiency-improved-glucose-metabolism-via-modulation-of-%ce%b2-cell-autophagy-on-high-fat-diet-mice"},"modified":"2026-04-29T03:11:37","modified_gmt":"2026-04-29T08:11:37","slug":"caveolin-1-deficiency-improved-glucose-metabolism-via-modulation-of-%ce%b2-cell-autophagy-on-high-fat-diet-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/caveolin-1-deficiency-improved-glucose-metabolism-via-modulation-of-%ce%b2-cell-autophagy-on-high-fat-diet-mice","title":{"rendered":"Caveolin-1 deficiency Improved Glucose Metabolism via Modulation of \u03b2-cell Autophagy on High-Fat-Diet Mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/caveolin-1-deficiency-improved-glucose-metabolism-via-modulation-of-ceb2-cell-autophagy-on-high-fat-diet-mice2.jpg\"><\/a><\/p>\n<p>New in JBC press.<\/p>\n<hr>\n<p>Lipotoxicity caused \u03b2-cell mass decrease and impaired \u03b2-cell function in type 2 diabetes mellitus (T2DM). We previously reported that caveolin-1 (Cav-1) deficiency protected pancreatic \u03b2 cells against palmitate (PA)-induced apoptosis and dysfunction in both NIT-1 cells and isolated islets. In this study, we firstly established inducible \u03b2-cell-specific Cav-1 knockout (i\u03b2-Cav1 KO) mice model. Next, we investigated whether Cav-1 depletion <i>in vitro<\/i> or <i>in vivo<\/i> affected \u03b2-cell function and survival through the regulation of autophagy under lipotoxicity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New in JBC press. Lipotoxicity caused \u03b2-cell mass decrease and impaired \u03b2-cell function in type 2 diabetes mellitus (T2DM). We previously reported that caveolin-1 (Cav-1) deficiency protected pancreatic \u03b2 cells against palmitate (PA)-induced apoptosis and dysfunction in both NIT-1 cells and isolated islets. In this study, we firstly established inducible \u03b2-cell-specific Cav-1 knockout (i\u03b2-Cav1 KO) [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-236108","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236108"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236108\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236108"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}