{"id":236078,"date":"2026-04-28T14:45:34","date_gmt":"2026-04-28T19:45:34","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/in-vivo-evolution-of-antibody-cr3022-expands-cross-neutralization-of-sars-cov-2-variants-and-informs-pan-sarbecovirus-immunity"},"modified":"2026-04-28T14:45:34","modified_gmt":"2026-04-28T19:45:34","slug":"in-vivo-evolution-of-antibody-cr3022-expands-cross-neutralization-of-sars-cov-2-variants-and-informs-pan-sarbecovirus-immunity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/in-vivo-evolution-of-antibody-cr3022-expands-cross-neutralization-of-sars-cov-2-variants-and-informs-pan-sarbecovirus-immunity","title":{"rendered":"In vivo evolution of antibody CR3022 expands cross-neutralization of SARS-CoV-2 variants and informs pan-sarbecovirus immunity"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/in-vivo-evolution-of-antibody-cr3022-expands-cross-neutralization-of-sars-cov-2-variants-and-informs-pan-sarbecovirus-immunity2.jpg\"><\/a><\/p>\n<p>Fu et al. use Ig-humanized mice expressing the germline CR3022 heavy chain to reveal how somatic hypermutation rapidly adapts this antibody class for broad sarbecovirus recognition. Sequential immunization drives CR3022-like maturation, while structural analyses show that increased affinity and breadth arise from subtle polar and electrostatic refinements.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fu et al. use Ig-humanized mice expressing the germline CR3022 heavy chain to reveal how somatic hypermutation rapidly adapts this antibody class for broad sarbecovirus recognition. Sequential immunization drives CR3022-like maturation, while structural analyses show that increased affinity and breadth arise from subtle polar and electrostatic refinements.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,385],"tags":[],"class_list":["post-236078","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-evolution"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236078","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236078"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236078\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236078"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236078"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236078"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}