{"id":236057,"date":"2026-04-28T06:09:23","date_gmt":"2026-04-28T11:09:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/early-fibrotic-niches-establish-tumour-permissive-microenvironments"},"modified":"2026-04-28T06:09:23","modified_gmt":"2026-04-28T11:09:23","slug":"early-fibrotic-niches-establish-tumour-permissive-microenvironments","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/early-fibrotic-niches-establish-tumour-permissive-microenvironments","title":{"rendered":"Early fibrotic niches establish tumour-permissive microenvironments"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/early-fibrotic-niches-establish-tumour-permissive-microenvironments.jpg\"><\/a><\/p>\n<p>Pathologic transformation in KrasG12D-mutant alveolar type II cells initiates a tumour-permissive niche by orchestrating epithelial, stromal and immune reprogramming through amphiregulin\u2013EGFR signalling, creating a self-sustaining circuit critical for lung tumour initiation and progression.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pathologic transformation in KrasG12D-mutant alveolar type II cells initiates a tumour-permissive niche by orchestrating epithelial, stromal and immune reprogramming through amphiregulin\u2013EGFR signalling, creating a self-sustaining circuit critical for lung tumour initiation and progression.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-236057","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236057","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236057"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236057\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236057"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236057"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236057"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}