{"id":236048,"date":"2026-04-27T22:55:42","date_gmt":"2026-04-28T03:55:42","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/oxidative-stress-induced-astrocytic-collagen-biosynthesis-drives-glial-barrier-formation-and-neuronal-death-in-ischemic-stroke"},"modified":"2026-04-27T22:55:42","modified_gmt":"2026-04-28T03:55:42","slug":"oxidative-stress-induced-astrocytic-collagen-biosynthesis-drives-glial-barrier-formation-and-neuronal-death-in-ischemic-stroke","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/oxidative-stress-induced-astrocytic-collagen-biosynthesis-drives-glial-barrier-formation-and-neuronal-death-in-ischemic-stroke","title":{"rendered":"Oxidative stress-induced astrocytic collagen biosynthesis drives glial barrier formation and neuronal death in ischemic stroke"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/oxidative-stress-induced-astrocytic-collagen-biosynthesis-drives-glial-barrier-formation-and-neuronal-death-in-ischemic-stroke2.jpg\"><\/a><\/p>\n<p>Online now: Lee et al. demonstrate that oxidative stress reprograms astrocytes to produce collagen through glycosylation-dependent mechanisms, driving glial barrier formation and progressive neuronal death after stroke. Targeting this pathway disrupts the glial barrier, prevents neurodegeneration, and improves functional recovery. A drug candidate, KDS12025, shows a potent effect in a non-human primate stroke model.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Online now: Lee et al. demonstrate that oxidative stress reprograms astrocytes to produce collagen through glycosylation-dependent mechanisms, driving glial barrier formation and progressive neuronal death after stroke. Targeting this pathway disrupts the glial barrier, prevents neurodegeneration, and improves functional recovery. A drug candidate, KDS12025, shows a potent effect in a non-human primate stroke model.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-236048","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236048","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=236048"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/236048\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=236048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=236048"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=236048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}