{"id":235961,"date":"2026-04-26T22:07:50","date_gmt":"2026-04-27T03:07:50","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/oxidative-stress-causes-a-reversible-decrease-of-deubiquitylases-activity-in-old-vertebrate-brains"},"modified":"2026-04-26T22:07:50","modified_gmt":"2026-04-27T03:07:50","slug":"oxidative-stress-causes-a-reversible-decrease-of-deubiquitylases-activity-in-old-vertebrate-brains","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/oxidative-stress-causes-a-reversible-decrease-of-deubiquitylases-activity-in-old-vertebrate-brains","title":{"rendered":"Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/oxidative-stress-causes-a-reversible-decrease-of-deubiquitylases-activity-in-old-vertebrate-brains.jpg\"><\/a><\/p>\n<p>Activity-based proteomics reveals a conserved decline in deubiquitylating enzyme activity in the aging vertebrate brain driven by oxidative stress. Antioxidant treatment restores activity, identifying redox-sensitive DUBs as early drivers of proteostasis decline.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Activity-based proteomics reveals a conserved decline in deubiquitylating enzyme activity in the aging vertebrate brain driven by oxidative stress. Antioxidant treatment restores activity, identifying redox-sensitive DUBs as early drivers of proteostasis decline.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269,47],"tags":[],"class_list":["post-235961","post","type-post","status-publish","format-standard","hentry","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235961"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235961\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235961"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235961"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}