{"id":235957,"date":"2026-04-26T14:05:16","date_gmt":"2026-04-26T19:05:16","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/engineered-internal-architecture-of-core-shell-lipid-nanoparticles-promotes-efficient-mrna-endosomal-release"},"modified":"2026-04-26T14:05:16","modified_gmt":"2026-04-26T19:05:16","slug":"engineered-internal-architecture-of-core-shell-lipid-nanoparticles-promotes-efficient-mrna-endosomal-release","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/engineered-internal-architecture-of-core-shell-lipid-nanoparticles-promotes-efficient-mrna-endosomal-release","title":{"rendered":"Engineered internal architecture of core-shell lipid nanoparticles promotes efficient mRNA endosomal release"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/engineered-internal-architecture-of-core-shell-lipid-nanoparticles-promotes-efficient-mrna-endosomal-release2.jpg\"><\/a><\/p>\n<p>Li <i>et al.<\/i> show that putting gold nanoparticles inside of LNPs causes marked improvements in endosomal escape efficiency, describe a likely mechanism, and test their complexes with two therapeutic contexts in mice. A simple innovation which could greatly enhance LNP delivery!<\/p>\n<hr>\n<p>Lipid Nanoparticles (LNPs) effectively deliver mRNA to cells but suffer have low levels of endosomal release. Here the authors report on core-shell LNPs with ionizable lipid\u2013coated gold nanoparticle cores with enhanced pH-responsive membrane disruption, endosomal escape, and cytosolic mRNA delivery improving therapeutic efficiency.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Li et al. show that putting gold nanoparticles inside of LNPs causes marked improvements in endosomal escape efficiency, describe a likely mechanism, and test their complexes with two therapeutic contexts in mice. A simple innovation which could greatly enhance LNP delivery! Lipid Nanoparticles (LNPs) effectively deliver mRNA to cells but suffer have low levels of [\u2026]<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1522,4],"tags":[],"class_list":["post-235957","post","type-post","status-publish","format-standard","hentry","category-innovation","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235957"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235957\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}