{"id":235860,"date":"2026-04-24T18:23:16","date_gmt":"2026-04-24T23:23:16","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/subversion-of-kynurenine-induced-ahr-activation-in-cd8-t-cells-by-kynureninase-expressing-antigen-presenting-cells"},"modified":"2026-04-24T18:23:16","modified_gmt":"2026-04-24T23:23:16","slug":"subversion-of-kynurenine-induced-ahr-activation-in-cd8-t-cells-by-kynureninase-expressing-antigen-presenting-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/subversion-of-kynurenine-induced-ahr-activation-in-cd8-t-cells-by-kynureninase-expressing-antigen-presenting-cells","title":{"rendered":"Subversion of kynurenine-induced AHR activation in CD8 T cells by kynureninase-expressing antigen-presenting cells"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/subversion-of-kynurenine-induced-ahr-activation-in-cd8-t-cells-by-kynureninase-expressing-antigen-presenting-cells.jpg\"><\/a><\/p>\n<p>Giacomantonio et al. demonstrate an immunomodulatory role for a metabolic enzyme kynureninase in antigen-presenting cells (APCs). Kynureninase-expressing APCs degrade kynurenine, including that generated by cancer cells, and relieve kynurenine-induced immunosuppression in CD8+ T cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Giacomantonio et al. demonstrate an immunomodulatory role for a metabolic enzyme kynureninase in antigen-presenting cells (APCs). Kynureninase-expressing APCs degrade kynurenine, including that generated by cancer cells, and relieve kynurenine-induced immunosuppression in CD8+ T cells.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-235860","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235860","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235860"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235860\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235860"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235860"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235860"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}