{"id":235852,"date":"2026-04-24T14:20:23","date_gmt":"2026-04-24T19:20:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/identification-and-characterization-of-braf%e2%87%94tp53-interactions-in-melanoma"},"modified":"2026-04-24T14:20:23","modified_gmt":"2026-04-24T19:20:23","slug":"identification-and-characterization-of-braf%e2%87%94tp53-interactions-in-melanoma","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/identification-and-characterization-of-braf%e2%87%94tp53-interactions-in-melanoma","title":{"rendered":"Identification and characterization of BRAF\u21d4TP53 interactions in melanoma"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/identification-and-characterization-of-brafe28794tp53-interactions-in-melanoma2.jpg\"><\/a><\/p>\n<p>O\u2019Toole et al. identify novel interactors of both normal BRAF and BRAFV600E and discover TP53 as a BRAFV600E-enhanced interactor in melanoma cells. While TP53 mutations do not frequently occur in melanoma, the authors demonstrate TP53 inactivation and a sequestration of cytoplasmic TP53 after oncogenic BRAF activation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>O\u2019Toole et al. identify novel interactors of both normal BRAF and BRAFV600E and discover TP53 as a BRAFV600E-enhanced interactor in melanoma cells. While TP53 mutations do not frequently occur in melanoma, the authors demonstrate TP53 inactivation and a sequestration of cytoplasmic TP53 after oncogenic BRAF activation.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-235852","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235852","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235852"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235852\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235852"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235852"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235852"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}